Effects of catheter-based renal denervation in hypertension: a systematic review and meta-analysis.
Davor VukadinovićLucas LauderDavid E KandzariDeepak L BhattAjay J KirtaneElazer R EdelmanRoland Erich SchmiederMichel AziziMichael BöhmFelix MahfoudPublished in: medRxiv : the preprint server for health sciences (2024)
What is new?Several sham-controlled trials have investigated the efficacy and safety of catheter-based renal denervation (RDN) with mixed outcomes.This comprehensive meta-analysis comprising 2,478 patients shows that irrespective of the utilized method (radiofrequency-, ultrasound-or alcohol-mediated), renal denervation effectively reduced ambulatory and office systolic blood pressure.Renal denervation exhibited no additional risk concerning vascular injury or renal function impairment.What are the clinical implications?This meta-analysis supports current guidelines/consensus statements that renal denervation represents an additive treatment option in carefully selected patients with uncontrolled hypertension.
Keyphrases
- blood pressure
- systematic review
- hypertensive patients
- end stage renal disease
- meta analyses
- heart rate
- magnetic resonance imaging
- newly diagnosed
- ejection fraction
- prognostic factors
- type diabetes
- mass spectrometry
- clinical practice
- peritoneal dialysis
- left ventricular
- adipose tissue
- atrial fibrillation
- case control
- blood glucose
- high resolution
- insulin resistance
- combination therapy
- single molecule
- catheter ablation
- glycemic control