Chemotherapy impairs skeletal muscle mitochondrial homeostasis in early breast cancer patients.
Joris MallardElyse HucteauAnne-Laure CharlesLaura BenderClaire BaezaMathilde PélissiePhilippe TrenszCarole PflumioMichal Kalish-WeindlingBernard GényRoland SchottFabrice FavretXavier PivotThomas J HureauAllan F PaganoPublished in: Journal of cachexia, sarcopenia and muscle (2022)
production, and (iv) increased initiation of apoptosis. All of these alterations likely explain, at least in part, the high prevalence of skeletal muscle and cardiorespiratory deconditioning classically observed in breast cancer patients.
Keyphrases
- skeletal muscle
- end stage renal disease
- early breast cancer
- oxidative stress
- insulin resistance
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- endoplasmic reticulum stress
- cell death
- body composition
- metabolic syndrome
- squamous cell carcinoma
- adipose tissue
- high intensity
- signaling pathway
- cell cycle arrest
- pi k akt
- patient reported