Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release.

Wei HuangMatthew C CaneRajarshi MukherjeePeter SzatmaryXiaoying ZhangVictoria ElliottYulin OuyangMichael ChvanovDiane LatawiecLi WenDavid M BoothAndrea C HaynesOle H PetersenAlexei V TepikinDavid N CriddleRobert Sutton

Published in: Gut (2015)

Caffeine and its dimethylxanthine metabolites reduced pathological IP3R-mediated pancreatic acinar Ca2+ signals but only caffeine ameliorated experimental AP. Caffeine is a suitable starting point for medicinal chemistry.

Keyphrases

ms ms
protein kinase
drug discovery