Smad3-mediated lncRNA HSALR1 enhances the non-classic signalling pathway of TGF-β1 in human bronchial fibroblasts by binding to HSP90AB1.
Erkang YiBiting LinYi ZhangXiaoyu WangJiahuan ZhangYu LiuJing JinWei HongZhiwei LinWeitao CaoXinyue MeiGe BaiBing LiYumin ZhouPixin RanPublished in: Clinical and translational medicine (2023)
Our results suggest that lncRNA HSALR1 binds to HSP90AB1 and Akt complex component, and enhances activity of the TGF-β1 smad3-independent pathway. This finding described here suggest that lncRNA can participate in COPD development, and HSLAR1 is a promising molecular target of COPD therapy.
Keyphrases
- transforming growth factor
- epithelial mesenchymal transition
- chronic obstructive pulmonary disease
- heat shock protein
- long non coding rna
- long noncoding rna
- lung function
- heat stress
- endothelial cells
- heat shock
- signaling pathway
- cell proliferation
- induced pluripotent stem cells
- extracellular matrix
- cystic fibrosis
- bone marrow