CircPAK1 promotes the progression of hepatocellular carcinoma via modulation of YAP nucleus localization by interacting with 14-3-3ζ.

Xiaopei HaoYao ZhangXiaoli ShiHanyuan LiuZhiying ZhengGuoyong HanDawei RongChuanyong ZhangWeiwei TangXuehao Wang

Published in: Journal of experimental & clinical cancer research : CR (2022)

CircPAK1 exerts its oncogenic function by competitively binding 14-3-3 ζ with YAP, thus promoting YAP nucleus localization, leading to the inactivation of a Hippo signaling pathway. Exosomal circPAK1 may drive resistance to lenvatinib, providing a potential therapeutic target for HCC patients.

Keyphrases

signaling pathway
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
epithelial mesenchymal transition
pi k akt
climate change
patient reported outcomes
human health
induced apoptosis
dna binding