Impact of granulocyte colony-stimulating factor on FOLFIRINOX-induced neutropenia prevention: A population pharmacokinetic/pharmacodynamic approach.

Pauline MacaireJustine ParisJulie VincentFrançois GhiringhelliLeïla Bengrine-LefevreAntonin Schmitt

Published in: British journal of clinical pharmacology (2020)

The PK/PD model well described our population's ANC data. Simulations showed that pegylated-G-CSF administration 24 hours after the end of chemotherapy seems to be the optimal schedule to reduce FOLFIRINOX-induced neutropenia. We also underline the potential negative effect of G-CSF maladministration.

Keyphrases

locally advanced
high glucose
diabetic rats
chemotherapy induced
endothelial cells
rectal cancer
radiation therapy
molecular dynamics
electronic health record
machine learning
cerebrospinal fluid
deep learning
peripheral blood
artificial intelligence
data analysis