Bleomycin induces fibrotic transformation of bone marrow stromal cells to treat height loss of intervertebral disc through the TGFβR1/Smad2/3 pathway.
Xiao YangZhiqian ChenChen ChenChen HanYifan ZhouXunlin LiHaijun TianXiaofei ChengKai ZhangAn QinTangjun ZhouJie ZhaoPublished in: Stem cell research & therapy (2021)
Locally, injection of bleomycin in rats' IVD induced rapid fibrosis and maintained its height through the TGFβ-TGFβR1-SMAD2/3 signaling pathway.