Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K/AKT/NF-κB pathway and regulating NLRP3 inflammasome-mediated pyroptosis.

Yuhang GongJianxing QiuTing JiangZe LiWeikang ZhangXiaohang ZhengZixuan HeWeifu ChenZhangfu WangXingbing FengMeizhen WangZheng-Hua Hong

Published in: Inflammopharmacology (2022)

Our results suggest that MA slowed IDD development through the PI3K/AKT/NF-κB signaling pathway and NLRP3 inflammasome-mediated pyroptosis, indicating that MA appeared to be a viable medication for IDD treatment.

Keyphrases

nlrp inflammasome
signaling pathway
pi k akt
cell cycle arrest
induced apoptosis
epithelial mesenchymal transition
cell proliferation
healthcare
mouse model
lps induced
electronic health record
inflammatory response
smoking cessation