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Sinomenine Hydrochloride Protects IgA Nephropathy Through Regulating Cell Growth and Apoptosis of T and B Lymphocytes.

Jun-Jian LiLi LiShuang LiXin-Yi TangHui-Feng SunJian-Xin Liu
Published in: Drug design, development and therapy (2024)
SH exerts a dual regulation on the cell cycle and apoptosis of T and B cells by controlling cell cycle-related and apoptosis-associated proteins; it also reduces inflammatory cellular infiltration and mesangial proliferation. These are the major mechanisms of SH in IgAN.
Keyphrases
  • cell cycle
  • oxidative stress
  • cell proliferation
  • cell cycle arrest
  • endoplasmic reticulum stress
  • cell death
  • pi k akt
  • signaling pathway
  • diabetic nephropathy
  • endothelial cells