An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes.
Yuanyuan DaiNadezda IgnatyevaHang XuRuheen WaliKarl ToischerSören BrandenburgChristof LenzJulius Ryan D ProntoFunsho E FakuadeSamuel SossallaElisabeth M ZeisbergAndreas JanshoffIngo KutschkaNiels VoigtHenning UrlaubTorsten Bloch RasmussenJens MogensenStephan E LehnartGerd HasenfussAntje EbertPublished in: Circulation research (2023)
Our findings suggest that impaired endocytosis and cargo transport resulting in subcellular iron deficiency could be a relevant pathomechanism for patients with DCM carrying inherited mutations. Insight into this molecular mechanism may contribute to the development of treatment strategies and risk management in heart failure.