The Parkinson's Disease Mendelian Randomization Research Portal.

Alastair J NoyceSara Bandres-CigaJonggeol KimKarl HeilbronDemis KiaGibran HemaniAngli XueDebbie A LawlorGeorge Davey SmithRaquel DuranZiv Gan-OrCornelis BlauwendraatJ Raphael Gibbsnull nullDavid A HindsJian YangPeter VisscherJack CuzickHuw MorrisJohn HardyNicholas W WoodMike A NallsAndrew B Singleton

Published in: Movement disorders : official journal of the Movement Disorder Society (2019)

We present a new platform which offers Mendelian randomization analyses for a total of 5,839 genome-wide association studies versus the largest PD genome-wide association studies available (https://pdgenetics.shinyapps.io/MRportal/). Alongside, we report further evidence to support a causal role for adiposity on lowering the risk of PD. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

genome wide association
case control
insulin resistance
high throughput
systematic review
metabolic syndrome
type diabetes
adipose tissue
weight gain
physical activity
single cell