Effects of pentoxifylline and tocopherol on a rat-irradiated jaw model using micro-CT cortical bone analysis.

Truc Thi Hoang Nguyen Mi Young Eo Mi Hyun Seo Hoon Myoung Soung Min Kim Jong Ho Lee

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2019)

We found that a combination of PTX and TP improved quality and quantity of cortical bone in irradiated rat mandibles, thus providing supporting evidence of its utility as a treatment and prophylactic agent in ORN. We observed inadequate volumes of cortical and cancellous bone in ORN mandibles, suggesting that cortical bone could play an important role in further ORN studies.

Keyphrases

bone mineral density
soft tissue
bone loss
bone regeneration
oxidative stress
postmenopausal women
computed tomography
magnetic resonance imaging
positron emission tomography
contrast enhanced
image quality
quality improvement
dual energy