Long-term cortisol stress response in depression and comorbid anxiety is linked with reduced N-acetylaspartate in the anterior cingulate cortex.
Linda M BonnekohStephanie SeidenbecherKatrin KniggeAnne-Kathrin HüneckeCoraline D MetzgerClaus TempelmannMartin KanowskiJörn KaufmannGabriela Meyer-LotzKonstantin SchlaaffHenrik DobrowolnyLeonardo TozziDorothee Maria GescherJohann SteinerClemens KirschbaumThomas FrodlPublished in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2022)
Our results suggest a relationship between NAA metabolism in ACC and HPA axis activity as represented by long-term cortisol output.