Hypothermia modulates myeloid cell polarization in neonatal hypoxic-ischemic brain injury.
Marina SeitzChristian KösterMark DzietkoHemmen SabirMeray SerdarUrsula Felderhoff-MüserIvo BendixJosephine HerzPublished in: Journal of neuroinflammation (2021)
Our data demonstrate that HT-induced neuroprotection is preceded by acute suppression of HI-induced upregulation of inflammatory genes in myeloid cells and decreased infiltration of peripheral macrophages, both representing potential important effector mechanisms of HT.
Keyphrases
- brain injury
- subarachnoid hemorrhage
- dendritic cells
- high glucose
- drug induced
- diabetic rats
- cerebral ischemia
- induced apoptosis
- acute myeloid leukemia
- bone marrow
- cardiac arrest
- single cell
- gene expression
- liver failure
- stem cells
- cell proliferation
- signaling pathway
- electronic health record
- genome wide
- respiratory failure
- machine learning
- intensive care unit
- cell cycle arrest
- hepatitis b virus
- extracorporeal membrane oxygenation
- transcription factor
- type iii