Temozolomide-induced myelotoxicity and single nucleotide polymorphisms in the MGMT gene in patients with adult diffuse glioma: a single-institutional pharmacogenetic study.

Prithwijit MoitraAbhishek ChatterjeePriti Khatri KotaSridhar EpariVijay PatilArchya DasguptaPradnya KowtalRajiv SarinTejpal Gupta

Published in: Journal of neuro-oncology (2022)

There is substantially higher frequency of variant T allele (L84F) in Indian patients than previously reported for South Asians. The presence of specific SNPs in the MGMT gene correlates with prolonged duration but not severity of TMZ-induced myelotoxicity.

Keyphrases

genome wide
high glucose
newly diagnosed
end stage renal disease
diabetic rats
ejection fraction
chronic kidney disease
copy number
drug induced
oxidative stress
endothelial cells
dna methylation
gene expression
patient reported outcomes
transcription factor
patient reported