Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival.
Jung S ByunSandeep K SinghalSamson ParkDae Ik YiTingfen YanAmbar CabanAlana C JonesPartha MukhopadhyaySara M GilStephen M HewittLisa NewmanMelissa B DavisBrittany D JenkinsJorge L SepulvedaAdriana De SierviAnna Maria NapolesNasreen A VohraKevin GardnerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Even within clinically homogeneous tumor groups, regulatory networks that drive mammary luminal differentiation reveal race-specific differences in their association with clinical outcome. Understanding these biomarkers and their downstream regulons will elucidate the intrinsic mechanisms that drive racial disparities in breast cancer survival.