Therapeutic Targeting of SDHB-Mutated Pheochromocytoma/Paraganglioma with Pharmacologic Ascorbic Acid.

Yang LiuYing PangBoqun ZhuOndrej UherVeronika CaisovaThanh-Truc HuynhDavid TaiebKaterina Hadrava VanovaHans Kumar GhayeeJiri NeuzilMark LevineChunzhang YangKarel Pacak

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

The data here demonstrate that targeting redox homeostasis as a cancer vulnerability with pharmacologic ascorbic acid is a promising therapeutic strategy for SDHB-mutated PCPGs.

Keyphrases

cancer therapy
papillary thyroid
climate change
electronic health record
squamous cell
squamous cell carcinoma
drug delivery
young adults
lymph node metastasis
data analysis