Increased TP53 somatic evolution in peritoneal washes of individuals with BRCA1 germline mutations.
Xin Ray TeeEmma HazardElena Latorre-EstevesBrendan F KohrnTalayeh S GhezelayaghJeanne Uy FredricksonCoohleenAnn CoombesMarc R RadkeEnna ManhardtRonit KatzT Rinda SoongElizabeth M SwisherBarbara M NorquistRosa Ana RisquesPublished in: Gynecologic oncology (2024)
Ultra-deep sequencing of TP53 mutations in peritoneal washes collected at surgery reveals increased burden of pathogenic TP53 mutations in BRCA1 carriers. This excess of pathogenic TP53 mutations might be linked to the elevated risk of HGSC in these individuals. In some patients, concordant TP53 mutations were found in peritoneal washes and cervical LBCs, but the cell of origin remains unknown and deserves further investigation.