Optimization of pre-analytical heat treatment for inhibitor detection in haemophilia A.

Published in: International journal of laboratory hematology (2018)

PHT at 58°C for 30 minutes demonstrated consistent reduction in FVIII:C < 1IU/dL without appearing to affect inhibitor detection. Laboratory awareness of differences in thermostability of different sources of FVIII is important when choosing PHT conditions.

Keyphrases

loop mediated isothermal amplification
real time pcr
label free
drinking water
heat stress
combination therapy
sensitive detection
smoking cessation