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Ethanol disrupts hepatocellular lipophagy by altering Rab5-centric LD-lysosome trafficking.

Micah B SchottCody N RozeveldSaumya BhattBridget CrossmanEugene W KruegerShaun G WellerKaruna RasineniCarol A CaseyMark A McNiven
Published in: Hepatology communications (2024)
These findings support the novel premise of an early endosomal/multivesicular body intermediate compartment on the LD surface that provides a "docking" site for lysosomal trafficking, not unlike the process that occurs during the hepatocellular degradation of endocytosed ligands that is also known to be compromised by EtOH exposure.
Keyphrases
  • molecular dynamics
  • molecular dynamics simulations
  • protein protein
  • fluorescent probe