Observational study on the prognostic value of testosterone and adiposity in postmenopausal estrogen receptor positive breast cancer patients.
Elisabetta VenturelliAnnalisa OrentiAline S C FabricioGiulia GarroneRoberto AgrestiBiagio PaoliniChiara BoniniMassimo GionFranco BerrinoChristine DesmedtDanila CoradiniElia BiganzoliPublished in: BMC cancer (2018)
In ER-positive postmenopausal breast cancer patients, high testosterone levels are associated with worse prognosis in normal-weight and overweight women, whereas in obese seems to be associated with a better outcome. Although the results require further validation, they suggest that assessment of circulating testosterone and BMI could help to identify postmenopausal ER-positive patients at higher risk of relapse and potentially open new therapeutic strategies.
Keyphrases
- estrogen receptor
- positive breast cancer
- weight loss
- weight gain
- replacement therapy
- bone mineral density
- breast cancer risk
- body mass index
- end stage renal disease
- ejection fraction
- physical activity
- newly diagnosed
- chronic kidney disease
- type diabetes
- insulin resistance
- metabolic syndrome
- polycystic ovary syndrome
- adipose tissue
- bariatric surgery
- endoplasmic reticulum
- pregnant women
- patient reported outcomes
- free survival
- body composition
- obese patients
- skeletal muscle
- body weight
- patient reported