MED1 Regulates BMP/TGF-β in Endothelium: Implication for Pulmonary Hypertension.
Chen WangYuanming XingJiao ZhangMing HeJianjie DongShanshan ChenHaoyu WuHsi-Yuan HuangChih-Hung ChouLiang BaiFangzhou HeJianqing SheAiling SuYouhua WangPatricia A ThistlethwaiteHsien-Da HuangJason X-J YuanZu-Yi YuanJohn Y-J ShyyPublished in: Circulation research (2022)
A homeostatic regulation of BMPR2, ERG, and TGFBR2 in ECs by MED1 synergistic with KLF4 is essential for the normal function of the pulmonary endothelium. Dysregulation of MED1 and the resulting impairment of the BMP/TGF-β signaling is implicated in the disease progression of PAH in humans and PH in rodent models.