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Fresh Osteochondral Allograft Transplantation in the Knee: A Viability and Histologic Analysis for Optimizing Graft Viability and Expanding Existing Standard Processed Graft Resources Using a Living Donor Cartilage Program.

Mario HevesiJanet M DenbeighCarlo A PaggiCatalina Galeano-GarcesLeila BagheriA Noelle LarsonMichael J StuartDaniel B F SarisChristopher R ParadiseAaron John Krych
Published in: Cartilage (2019)
Osteochondral tissue viability and histologic quality progressively decreases with ex vivo storage, even when kept at physiologic temperatures. Currently available clinical OCAs are stored for 2 to 5 weeks prior to implantation and demonstrate inferior viability to that of fresh osteochondral tissues that can be made available through the use of a living donor cartilage program.
Keyphrases
  • quality improvement
  • platelet rich plasma
  • total knee arthroplasty
  • gene expression
  • extracellular matrix
  • cell therapy
  • knee osteoarthritis
  • kidney transplantation
  • ionic liquid