APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett's-associated esophageal adenocarcinomas.
Farah BalloutHeng LuLei ChenKannappan SriramajayamJianwen QueZhipeng MengTimothy C WangSilvia GiordanoAlexander ZaikaOliver McDonaldDunfa PengWael El-RifaiPublished in: Journal of experimental & clinical cancer research : CR (2022)
Our findings established a novel function of APE1 in EAC progression elucidating druggable molecular vulnerabilities via targeting APE1 or YAP1 for the treatment of EAC.
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