Exploring the relationship between metabolism and immune microenvironment in osteosarcoma based on metabolic pathways.

Changwu WuJun TanHong ShenChao DengChristian KleberGeorg OsterhoffNikolas Schopow

Published in: Journal of biomedical science (2024)

The metabolism of vitamins and cofactors is an important prognostic regulator of TIME in osteosarcoma, MRG-related gene clusters can well reflect changes in osteosarcoma TIME and predict chemotherapy and immunotherapy response. The metabolism-related risk model may serve as a useful prognostic predictor. ST3GAL4 plays a critical role in the progression, glycolysis, and TIME of osteosarcoma cells.

Keyphrases

induced apoptosis
stem cells
transcription factor
cell cycle arrest
squamous cell carcinoma
radiation therapy
locally advanced
dna methylation
copy number
cell death
signaling pathway
genome wide identification
genome wide analysis