A potential mechanism of the onset of acute eosinophilic pneumonia triggered by an anti-PD-1 immune checkpoint antibody in a lung cancer patient.

Takayuki JodaiChieko YoshidaRyo SatoYosuke KakiuchiNahoko SatoShinji IyamaTomoko KimuraKoichi SaruwatariSho SaekiHidenori IchiyasuKazuhiko FujiiYusuke Tomita

Published in: Immunity, inflammation and disease (2018)

Given the increasing frequency of the use of anti-PD-1 antibodies, clinicians should be aware of the risk of AEP as a potential irAE. This study may improve our understanding of the pathophysiology underlying Th2-associated irAEs and AEP.

Keyphrases

respiratory failure
liver failure
case report
palliative care
intensive care unit
mechanical ventilation