TRPV2-induced Ca2+-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.

Hua BaiHuayuan ZhuQing YanXuxing ShenXiupan LuJuejin WangJianyong LiLijuan Chen

Published in: Cell communication and signaling : CCS (2018)

Our study uncovers the possible roles of TRPV2, which enhances MBD, suggesting that targeting osteocyte-MM cells interactions through blockade of TRPV2 channel may provide a promising treatment strategy in MM.

Keyphrases

neuropathic pain
multiple myeloma
induced apoptosis
cell cycle arrest
high glucose
diabetic rats
cancer therapy
spinal cord
drug induced
endothelial cells
drug delivery
cell death
cell proliferation
toll like receptor
nuclear factor
replacement therapy
smoking cessation