Associations Between Smoking and Primary Sjögren Syndrome Classification Using the Sjögren's International Collaborative Clinical Alliance Cohort.
Elisabeth A GebreegziabherCatherine E OldenburgStephen C ShiboskiAlan N BaerRichard C JordanJennifer R Rose-NussbaumerVatinee Y BunyaEsen K AkpekLindsey A CriswellCaroline H ShiboskiThomas M LietmanJohn A GonzalesPublished in: ACR open rheumatology (2021)
Compared with never smokers, current smokers in the SICCA cohort had lower odds of being classified as having pSS, lower odds of exhibiting abnormal signs and test results for dry eye disease, and lower odds of having a labial salivary gland biopsy supportive of pSS classification. Such negative associations, however, do not suggest that current smoking is of any benefit with respect to pSS.