The exon 19-deleted EGFR undergoes ubiquitylation-mediated endocytic degradation via dynamin activity-dependent and -independent mechanisms.
Taishu WangJinrui ZhangShanshan WangXiuna SunDuchuang WangYurou GaoYang ZhangLu XuYue WuYueguang WuFang LiuXiuxiu LiuShuyan LiuYingqiu ZhangYang WangLijuan ZouHan LiuPublished in: Cell communication and signaling : CCS (2018)
The internalized EGFR mutant is constantly routed through endosome to lysosome for degradation. The endocytosis of EGFR mutant occurs through both dynamin activity-dependent and -independent mechanisms. Our findings gain novel insights into the endocytic regulation of mutated EGFR and may have potential clinical implications.