Physiologic expansion of human heart-derived cells enhances therapeutic repair of injured myocardium.

Seth MountPushpinder KandaSandrine ParentSaad KhanConnor MichieLiliana DavilaVincent ChanRoss A DaviesHaissam HaddadDavid CourtmanDuncan J StewartDarryl R Davis

Published in: Stem cell research & therapy (2019)

Continuous physiological cell culture increased cell growth, paracrine output, and treatment outcomes to provide the greatest functional benefit after experimental myocardial infarction.

Keyphrases

induced apoptosis
heart failure
endothelial cells
cell cycle arrest
left ventricular
induced pluripotent stem cells
atrial fibrillation
signaling pathway
oxidative stress
cell death