Thermoresponsive Coiled-Coil Peptide-Polymer Grafts.
Nicole I HalaszynskiJeffery G SavenDarrin J PochanChristopher J KloxinPublished in: Bioconjugate chemistry (2023)
Alkyl halide side groups are selectively incorporated into monodispersed, computationally designed coiled-coil-forming peptide nanoparticles. Poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) is polymerized from the coiled-coil periphery using photoinitiated atom transfer radical polymerization (photoATRP) to synthesize well-defined, thermoresponsive star copolymer architectures. This facile synthetic route is readily extended to other monomers for a range of new complex star-polymer macromolecules.