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Identification of 58 novel HLA alleles identified in Chinese individuals by next-generation sequencing.

Stephen K F CheungLeo C W ChoiY S ChanJenny C Y HoCheuk Kwong LeeJanette S Y Kwok
Published in: HLA (2023)
HLA genes are the most polymorphic in the human genome. High resolution HLA typing from 13,870 bone marrow donors in Hong Kong was obtained using Next-generation sequencing (NGS) technology. Among the 67 novel alleles identified, official HLA allele names of 50 novel class I alleles (HLA-A, -B, -C) and 8 novel class II alleles (HLA-DRB1, -DQB1) were assigned by the World Health Organization (WHO) Nomenclature Committee for Factors of the HLA System.
Keyphrases
  • bone marrow
  • high resolution
  • endothelial cells
  • mesenchymal stem cells
  • genome wide
  • copy number
  • dna methylation
  • transcription factor
  • high speed
  • circulating tumor
  • induced pluripotent stem cells
  • genetic diversity