Is intravitreal topotecan toxic to retinal function?

Jennifer B Nadelmann Jasmine H FrancisScott E BrodieEngjel MucaDavid H Abramson

Published in: The British journal of ophthalmology (2020)

Intravitreal topotecan combined with intravitreal melphalan was associated with a decrease in ERG amplitude; there was not a significant decrease in ERG amplitude observed in patients who received topotecan alone. These findings suggest that intravitreal topotecan injections at doses of 20 μg or 30 μg are not associated with retinal toxicity in patients with retinoblastoma.

Keyphrases

diabetic retinopathy
vascular endothelial growth factor
age related macular degeneration
optical coherence tomography
resting state
oxidative stress
endothelial cells
optic nerve
functional connectivity