Cannabinoid receptor 2 plays a key role in renal fibrosis through inhibiting lipid metabolism in renal tubular cells.

Shan ZhouXian LingYe LiangQijian FengChao XieJiemei LiQiyan ChenJinhua MiaoMengyao ZhangZhiru LiWeiwei ShenXiaolong LiQinyu WuXiaoxu WangFan Fan HouYouhua LiuYaozhong KongLili Zhou

Published in: Metabolism: clinical and experimental (2024)

This study highlights CB2 disrupts FAO in tubular cells through β-catenin activation and subsequent inhibition on PPARα/PGC-1α activity. Targeted inhibition on CB2 offers a perspective therapeutic strategy to fight against renal fibrosis.

Keyphrases

induced apoptosis
cell cycle arrest
skeletal muscle
endoplasmic reticulum stress
epithelial mesenchymal transition
metabolic syndrome
oxidative stress
cancer therapy
liver fibrosis
pi k akt
high glucose
binding protein