RTS,S/AS01E immunization increases antibody responses to vaccine-unrelated Plasmodium falciparum antigens associated with protection against clinical malaria in African children: a case-control study.
Carlota DobanoItziar UbillosChenjerai JairoceBen GyanMarta VidalAlfons JiménezRebeca SantanoDavid DosooAugusto J NhabombaAintzane AyestaranRuth AguilarNana Aba WilliamsNúria Díez-PadrisaDavid LanarVirander ChauhanChetan ChitnisSheetij DuttaDeepak GaurEvelina AngovKwaku Poku AsanteSeth Owusu-AgyeiClarissa ValimBenoit GamainRoss L CoppelDavid CavanaghJames G BeesonJoseph J CampoGemma MoncunillPublished in: BMC medicine (2019)
Increased antibody responses to specific P. falciparum antigens in subjects immunized with this partially efficacious vaccine upon natural infection may contribute to overall protective immunity against malaria. Inclusion of such antigens in multivalent constructs could result in more efficacious second-generation multistage vaccines.