Cerebrospinal fluid glutamate changes in functional movement disorders.
Benedetta DemartiniRoberto William InvernizziLaura CampiglioTommaso BocciAndrea D'ArrigoAndrea ArighiFrancesca SciaccaDaniela GalimbertiElio ScarpiniOrsola GambiniAlberto PrioriPublished in: NPJ Parkinson's disease (2020)
The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.