USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.

Jianjun LiXuechun XiaoYang OuLixia CaoMin GuoChunchun QiZhaoyang WangYuxin LiuQiuying ShuaiHang WangPeiqing SunYi ShiGuang YangShuang Yang

Published in: Cancer communications (London, England) (2023)

Together, our results demonstrated that the USP51/PD-L1/ITGB1 network potentially contributes to the malignant progression and therapeutic resistance in NSCLC. This knowledge is beneficial to the future design of advanced cancer therapy.

Keyphrases

cancer therapy
small cell lung cancer
drug delivery
single cell
healthcare
cell therapy
current status
advanced non small cell lung cancer
stem cells
brain metastases