Encephalopathies Associated With Severe COVID-19 Present Neurovascular Unit Alterations Without Evidence for Strong Neuroinflammation.

Raphael Bernard-ValnetSylvain PerriotMathieu CanalesBeatrice PizzarottiLeonardo CaranzanoMayté Castro JimenezJean-Benoit EpineySergiu VijialaPaolo Salvioni-ChiabottiAngelica AnichiniAlexander Salerno Katia JatonJulien VaucherMatthieu PerreauGilbert GreubGiuseppe PantaleoRenaud A Du Pasquier

Published in: Neurology(R) neuroimmunology & neuroinflammation (2021)

Our results do not indicate active replication of SARS-CoV-2 in the CSF or signs of massive inflammation in the CSF compartment but highlight a specific impairment of the neurovascular unit linked to intrathecal production of CXCL8.

Keyphrases

sars cov
respiratory syndrome coronavirus
oxidative stress
coronavirus disease
traumatic brain injury
lipopolysaccharide induced
early onset
cerebrospinal fluid
inflammatory response
brain injury