Effects of Green Tea Extract on Atorvastatin Pharmacokinetics in Healthy Volunteers.

Khaled S AbdelkawyReham M AbdelazizAhmed M AbdelmageedAhmed M DoniaNoha M El-Khodary

Published in: European journal of drug metabolism and pharmacokinetics (2021)

Green tea extract decreases the absorption but not the elimination of atorvastatin, possibly by inhibiting OATP, albeit not in a dose-dependent manner. Coadministration of green tea extract with atorvastatin may necessitate the monitoring of the plasma concentration of atorvastatin in clinical practice.

Keyphrases

oxidative stress
clinical practice
anti inflammatory
signaling pathway