Nickel-catalyzed Suzuki Coupling of Cycloalkyl Silyl Peroxides with Boronic Acids.

Lei ChenJun-Cheng YangPengfei XuJun-Jie ZhangXin-Hua Duan Li Na Guo

Published in: The Journal of organic chemistry (2020)

A nickel-catalyzed Suzuki alkyl-aryl coupling of cycloalkyl silyl peroxides with boronic acids is reported. The primary and secondary ketoalkyl electrophiles generated through C-C bond cleavage were amenable, providing rapid access to a variety of distal arylated alkyl ketones. A radical pathway is proposed for this reaction.

Keyphrases

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