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Doxycycline attenuates chronic intermittent hypoxia-induced atrial fibrosis in rats.

Weiding WangKai ZhangXiongfeng LiZuowang MaYue ZhangMeng YuanYa SuoXue LiangGary TseChristos A GoudisTong LiuGuangping Li
Published in: Cardiovascular therapeutics (2018)
CIH treatment induced significant atrial fibrosis in our rat model, which was attenuated by doxycycline. These changes can be explained by alterations in the MMP and miR-21/ERK signaling pathways.
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