Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma.
Tyler J GleasonMichael HaasBrian H LePublished in: Case reports in radiology (2017)
A 76-year-old female with coronary artery disease, chronic obstructive pulmonary disease, diabetes mellitus type II, and 40 pack-year smoking history presented with a four-day history of cough, productive of green-yellow sputum. Chest X-ray revealed opacification of the left upper lung field, and computed tomography (CT) of the chest showed a large cavitary lesion invading the T2-T3 vertebral bodies, extending into the epidural space, giving rise to mild cord compression. Biopsy of the lesion revealed a poorly differentiated neoplasm composed of distinct epithelial and mesenchymal components, consistent with carcinosarcoma. A metastatic workup was negative. Primary lung carcinosarcoma is a rare tumour that can demonstrate an especially aggressive clinical course; diagnosis is often nuanced by limited sampling at initial presentation, especially in a setting of advanced disease and debility that precludes consideration for upfront resection or more extensive, invasive sampling.
Keyphrases
- dual energy
- computed tomography
- chronic obstructive pulmonary disease
- coronary artery disease
- high resolution
- image quality
- single cell
- positron emission tomography
- contrast enhanced
- squamous cell carcinoma
- cystic fibrosis
- mycobacterium tuberculosis
- stem cells
- pulmonary hypertension
- small cell lung cancer
- magnetic resonance imaging
- bone marrow
- lung function
- spinal cord
- low grade
- smoking cessation
- type diabetes
- pulmonary tuberculosis
- cardiovascular events
- percutaneous coronary intervention
- coronary artery bypass grafting
- ultrasound guided
- metabolic syndrome
- air pollution
- cardiovascular disease
- high grade
- heart failure
- left ventricular
- postmenopausal women
- weight loss