Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization.
Anna C F LewisEmma F PerezAnya E R PrinceHana R FlaxmanLizbeth GomezDeanna G BrockmanPaulette D ChandlerBenjamin J KermanMatthew S LeboJordan W SmollerScott T WeissCarrie L Blout ZawatksyJames B MeigsRobert C GreenJason L VassyElizabeth W KarlsonPublished in: Genome medicine (2022)
PCPs saw PRS information as a natural extension of their current practice. The most pressing gap for PRS implementation is evidence for clinical utility. Careful clinical report design can help ensure that benefits are realized and harms are minimized.