Is There Any Research Evidence Beyond Surveys and Opinion Polls on Automatic Substitution of Biological Medicines? A Systematic Review.

Hanna M TolonenJenni FalckPekka KurkiPäivi RuokoniemiKatri Hämeen-AnttilaKenneth M ShermockMarja Airaksinen

Published in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy (2021)

The current research evidence on the automatic substitution of biologics is scarce and of low to moderate quality, reflecting low stakeholder knowledge and their cautious attitude towards biosimilars. The safe and efficient implementation of automatic substitution requires well-designed practices, pilot studies, and evolving legislation.

Keyphrases

deep learning
healthcare
primary care
machine learning
quality improvement
neural network
high intensity