Transfer and loss of allergen-specific responses via stem cell transplantation: A prospective observational study.
Markus DebiasiHerbert PichlerFlorian KlinglmüllerHeidrun BoztugKlara SchmidthalerJonas RechDavid SchererChristian LupinekRudolph ValentaEwa Kacinska-PfallerRene GeyereggerGerhard FritschOskar A HaasChristina PetersThomas LionMübeccel AkdisSusanne MatthesCezmi A AkdisZsolt SzépfalusiThomas EiweggerPublished in: Allergy (2020)
Hematopoietic stem cell transplantation profoundly reduces allergen-specific IgE responses but also comes with a considerable risk to transfer allergen-specific immune responses. These findings facilitate clinical decision-making regarding allergic diseases in the context of hematopoietic stem cell transplantation. In addition, it provides prospective data to estimate the risk of transmitting allergen-specific responses via hematopoietic stem cell transplantation.