Neither amyloid depositions nor hepatic steatosis are associated with marginal islet mass early after autotransplantation.

In 2008 Westermark et al. postulated that amyloid depositions found in allotransplanted islets derived from either islet overstimulation due to insulin production (as in type 2 diabetes), toxicity of immunosuppression, or perhaps both.1 Amyloid depositions may promote a gradual decline in islet mass, progressive dysfunction, and ultimate failure. 2,3 Herein, for the first time, we report the histopathological examination of an entire liver following autologous islet transplantation which sheds new light on the etiology of amyloid deposition in islet allografts.