PGT-M, a Useful Tool to Manage the Lynch Syndrome Transmission.
Ilaria ListortiRoberta ManzoCristiana ArriviCecilia MencacciAnil BiricikErmanno GrecoPier Francesco GrecoPublished in: International journal of molecular sciences (2023)
Lynch syndrome is one of the most common hereditary cancer sensitivity syndromes and is caused by autosomal-dominant germline mutations in DNA mismatch repair genes. In patients affected by this syndrome, pre-implantation genetic testing for monogenic disorders (PGT-M) could be the elective technique used to prevent the transmission of this hereditary syndrome to offspring. Notably, despite the severity of the condition, some authors have observed a markedly lower demand for PGT-M in these patients compared to those with other hereditary conditions. A 34-year-old woman with a medical history of Lynch syndrome associated with endometrial cancer came to the Villa Mafalda fertility center in Rome in order to conceive a healthy baby. In a pre-implantation genetic testing for aneuploidy (PGT-A) + PGT-M cycle, eight blastocysts were formed. Six out of eight blastocysts were affected by the same mother syndrome. One of the other two was aneuploid and the other one was a mosaic embryo, which resulted in a healthy pregnancy. The aim of this report is to emphasize the importance of a multidisciplinary approach to managing patients with this condition. In vitro fertilization (IVF), specifically PGT-M, is a tool that allow patients to conceive biological children with lower risk of inheriting the disease.
Keyphrases
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- endometrial cancer
- case report
- peritoneal dialysis
- healthcare
- metabolic syndrome
- gene expression
- type diabetes
- dna methylation
- pregnant women
- oxidative stress
- young adults
- patient reported
- genome wide
- insulin resistance
- papillary thyroid
- childhood cancer