Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways.

Ya-Feng LiGayani NanayakkaraYu SunXinyuan LiLuqiao WangRamon CuetoYing ShaoHangfei FuCandice JohnsonJiali ChengXiongwen ChenWenhui HuJun YuEric T ChoiHong WangXiao-Feng Yang

Published in: Journal of hematology & oncology (2017)

Our findings suggest that caspase-1 regulates many new signaling pathways potentially via its known substrates and also via transcription factors and other proteins that are yet to be identified.

Keyphrases

transcription factor
induced apoptosis
cell death
signaling pathway
gene expression
single cell
pi k akt
dna binding