Differentially methylated DNA regions in early childhood wheezing: An epigenome-wide study using saliva.
Maja PopovićValentina FianoFrancesca FasanelliMorena TrevisanChiara GrassoManuela Bianca AssummaAnna Gillio-TosSilvia PolidoroLaura De MarcoFranca RusconiFranco MerlettiDaniela ZugnaLorenzo RichiardiPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2019)
This study suggests that PM20D1 hypermethylation is associated with early childhood wheezing. Directionally consistent epigenetic alteration observed in cord blood and other tissues at older ages in children with respiratory allergy and atopic asthma provides suggestive evidence that a long-term epigenetic modification, likely operating from birth, may be involved in childhood atopic phenotypes.
Keyphrases
- cord blood
- dna methylation
- gene expression
- atopic dermatitis
- chronic obstructive pulmonary disease
- young adults
- air pollution
- physical activity
- particulate matter
- lung function
- single molecule
- cell free
- gestational age
- middle aged
- heavy metals
- pregnant women
- risk assessment
- polycyclic aromatic hydrocarbons
- water soluble
- circulating tumor cells