Hydroxychloroquine Blood Concentrations Can Be Clinically Relevant Also After Drug Discontinuation.

Simona De GregoriFrancesco FalaschiAlessia BallesioAlessandra FuscoElisa CremonteRoberta CantaUmberto SabatiniMariadelfina MolinaroCarlo SoffiantiniAlba NardoneAlessandro VicentiniAnnalisa De SilvestriAntonio Di Sabatino

Published in: Drugs in R&D (2022)

The study confirms the long half-life of hydroxychloroquine and its effect on the corrected QT interval even after short-term courses of the drug. This can inform the clinician using hydroxychloroquine treatments that it would be safer to start or re-initiate treatments with corrected QT interval-prolonging potential 16 days after hydroxychloroquine discontinuation.

Keyphrases

drug induced
risk assessment
human health